BioAge Peptide Therapy
Peptides are defined as a compound of two or more amino acids in which a carboxyl group of one is united with an amino group of another. With the elimination of a water molecule, a peptide bond is formed. To put it more simply, peptides are just small proteins. When the number of amino acids are less than 50, these are peptides. When higher than 50, these are proteins. The peptides are therefore small chains of amino acid which are present in all cells of the body. These are synthesized naturally by the body. Peptides will therefore be used primarily to make a more abundant amount of hormones in the body.
These two peptides work synergistically generating 5x the benefits of either alone. This leads to fat loss and increases protein synthesis thereby promoting growth. Ipamorelin is a selective GH secretagogue. This peptide has less appetite stimulation compared to similar peptides and does not release as much cortisol or prolactin. This combination peptide is beneficial for improved body composition, as well as improved quality of deep sleep.
CJC outperforms the older GHRH, sermorelin, keeping a steady increase of HGH and IGF-1 with no increase of undesirable prolactin. CJC can be compounded in two forms (DAC and non-DAC). DAC is long acting (once weekly dosing) but has shown in studies to be less effective. Ipamorelin is considered to be the first selective GH secretagogue due to its ability to increase GH while not increasing other undesirable hormones as other secretagogues do.
Bremelanotide (PT 141)
PT141 was developed from the peptide hormone Melanotan. It is an effective peptide in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). Unlike popular ED drugs that act upon the vascular system, PT 141 increases sexual desire via the nervous system. Bremelanotide is used 30 minutes before sexual activity.
It is estimated that 43% of women (30 million in the US) suffer from female sexual dysfunction and 30 million men suffer from ED, with incidence increasing 2-3 fold between the ages of 40-70. Bremelanotide has no contraindication, such as hypotension, that can occur with other ED remedies and is 80% effective in people who do not respond to Viagra or Cialis.
Tesamorelin is a GHRH analog shown to reduce visceral fat, inflammatory markers, and carotid intima media thickness. Therefore, improvement in body composition, improvement in cognitive function (nootropic effect) and reduction of triglycerides are benefits seen with this peptide. Tesamorelin has demonstrated improvement in cognitive function for older healthy adults as well as for patients with mild cognitive impairment who are at risk of progression to Alzheimer’s disease.
Tesamorelin has been shown to increase IGF-1 levels in men by an average of 181 micrograms/L. Studies have also shown reductions in c-reactive protein (CRP), carotid intima media thickness (cIMT), and visceral adipose tissue (VAT). Additionally, it does not appear to increase glucose levels which can occur with some GHRHs.
“Body protection compound”157 is composed of 15 amino acids isolated from human gastric juice. This peptide has benefits both orally and subcutaneously. When BPC-157 is injected, it has demonstrated accelerated healing of wounds, including tendon-to-bone healing and superior healing of damaged ligaments. Orally, this peptide acts systemically in the digestive tract to combat leaky gut, IBS, gastro-intestinal cramps, and Crohn’s disease.
BPC 157 appears to protect organs and to prevent ulcers of the stomach. It has also been shown to reduce pain in damaged areas. Those who suffer discomfort due to muscle sprains, tears and damage can benefit from this peptide treatment. BPC 157 can also enhance the healing of different wounds to heal at a faster rate and increase blood flow to damaged tissues. This peptide can be helpful after injuries and surgical procedures.
Epithalon is the synthetic version of the polypeptide Epithalamin which is naturally produced in humans. Epithalon has many benefits, one of which being increasing a person’s resistance to emotional stress and also acting as an antioxidant. Epithalon has also been shown to increase telomere length in human cells. It has also been shown to normalize cholesterol and uric acid levels, restore pancreatic hormone function, and restore and normalize melatonin levels lost due to aging.
Epithalon is used in 80 day courses once to twice per year. In a randomized comparative study it was found that long term treatment over 3 years resulted in deceleration of aging of the cardiovascular system, prevention of age-associated impairment of physical endurance, normalized circadian rhythm of melatonin production and carbohydrate and lipid metabolism.
Cerebrolysin possesses neuroprotective and neurotrophic repair properties. The proteins of this peptide are small enough to cross the blood brain barrier and reach neurons directly. It has shown great potential in Alzheimer’s patients, as well as in other neurodegenerative diseases.
Cerebrolysin is a synthetic nootropic drug consisting of low molecular weight peptides. It has been proven to have neurotrophic action similar to nerve growth factors, which cause peripheral and central nervous system stimulation. It improves efficiency of the brain’s aerobic metabolic processes. The neuroprotective properties of this peptide shield neurons from lactacidosis, to prevent formation of free radicals.
Thymosin Beta 4
Thymosin is a naturally occurring hormone secreted from the thymus gland. While it is responsible for producing several hormones, it is associated with the immune system rather than with the endocrine system. Thymosin also assists in the production of antibodies. Thymosin plays an interesting role in tissue repair, where it demonstrates an ability to protect and regenerate injured tissues. We often see this being prescribed for post-surgical healing and acute injury.
Thymosin B4 stimulates the production of T cells. It also assists in the development of B cells to plasma cells to produce antibodies. Thymosin B4 is currently being trialed as a potential therapy for HIV, AIDS, and influenza.